HLA-DR15

HLA-DR15
Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
주요 조직 적합성 복합체, 클래스 II, DR15
하플로타입군 DRA*01:DRB1*1501 - ~ - DRA*01:DRB1*1505 DRA*01:DRB1*1507
구조(HLA-DR 참조)
식별자
알파 *0101
기호 HLA-DRA[영구적 데드링크]
EBI-HLA DRA*0101
식별자
베타 1 *1501 ~ *1505 *1507
기호 HLA-DRB1[영구적 데드링크]
EBI-HLA DRB1*1501
EBI-HLA DRB1*1502
EBI-HLA DRB1*1503
EBI-HLA DRB1*1504
EBI-HLA DRB1*1505
EBI-HLA DRB1*1507
공유 데이터
로커스 chr.6 6p21.31

HLA-DR15(DR15)는 DRB1*1501 ~ *1505 및 *1507 유전자 제품을 인식하는 HLA-DR 세로형이다.DR15는 아일랜드에서 중앙아시아까지 높은 수준에서 발견된다.DR15는 유사한 HLA-DR16 항원을 포함하는 이전 HLA-DR2 세로타입 그룹의 일부다.

병리학

일부 DRB1*15 알레르기의 DR15, DR2[1] 및 기타 세로형 인식
DRB1* DR15 DR2 DR16 샘플
얼싸안다 % % % 크기(N)
1501 76 23 6428
1502 77 16 676
1503 81 13 286
1504 >50 1
1505 >25 2
1507 >50 1

세로타입은 DRB1*1506, *1508 ~ *1516, *1518 ~ *1522 에 대해 알려져 있지 않다.DRB1*1517N은 null이다.

알레르스

질병 연관성

DR15는 굿파스 증후군,[2] 조기발견 다발성 경화증,[3] 과민성 빈혈,[4] 사코이데시스,[5] 저포크레틴 결핍증 관련 내실증[6][7] 및 폐경 후 골다공증 소인과 관련이 있다.[8]

DRB1*1501 긍정적으로 Goodpasture syndrome,[9][10]소아 류머티스 arthritis,[11]알레르기 기관지 폐의. aspergillosis,[12]여러 sclerosis,[13]체계적인 낭창 erythematosus,[14]자궁 경부 암(인 유두종 바이러스 감염)[15]Sjögren 증후군 체계적인 루푸스 erythematosus,[16]와 중간 uveit과 관련한 연관이 있다.is.[17]

DRB1*1502전신 루푸스 에리테마토스,[18] 전신 경화증(SSC) 및 항토포아세아제 항체와 관련이 있다.[19]

DRB1*1503차가의 심근병증,[20] 알레르기성 기관지 심폐 아스페르길루증,[12] 다발성 경화증,[13] 자궁경부암(인간 유피오마바이러스 감염)과 관련이 있다.[21]

확장연계

DRB1*15:DQA1*0102:DQB1*0602 happlotype us in 자궁경부암 위험 관련 haplotype us in (인간 파필로마바이러스 감염)[21]

DRB1*1502:DQA1*??:DQB1*0501 happlotype은 전신 루푸스 홍반과 연관됨[18]

유전자 연결

DR15 해플로타입스
세로타입스 DRA DRB1 DRB5
DR15(2)-DR51 *0101 *1501 *0101
*0101 *1502 *0101
*0101 *1503 *0101
*0101 *1504 *0101
*0101 *1505 *0101
*0101 *1507 *0101
DQA1 DQB1 DRB1
DR15(2)-DQ6(6.2, 1) *0102 *0602 *1501
DR15(2)-DQ6(6.1, 1) *0103 *0601 *1502
HLA-A HLA-B DRB1
A3-Cw7-B7-DR15(2) *0301 *0702 *1501
A1-B51-DR15(2) *0101 *5101 *1502

HLA-DR15는 HLA-DR51HLA-DQ6(HLA-DQ1) 세로형과 유전적으로 연결되어 있다.

참조

  1. ^ IMGT/HLA에서 파생됨
  2. ^ Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease". Int Immunol. 12 (8): 1135–43. doi:10.1093/intimm/12.8.1135. PMID 10917888.
  3. ^ Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis". Annals of Neurology. 48 (2): 211–9. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R. PMID 10939572.
  4. ^ Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed). 282 (6266): 768–70. doi:10.1136/bmj.282.6266.768. PMC 1504598. PMID 6783164.
  5. ^ Bilir M, Sipahi S, Yilmaz E, et al. (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. doi:10.1097/SMJ.0b013e31802f3763. PMID 17458393.
  6. ^ Hong SC, Lin L, Lo B, et al. (January 2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713.
  7. ^ Peled N, Amar A, Peled E, Brautbar C, Pillar G (2002). "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. doi:10.1016/S1389-9457(01)00155-1. PMID 14592217.
  8. ^ Douroudis K, Tarassi K, Athanassiades T, et al. (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
  9. ^ Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int. 68 (3): 1061–70. doi:10.1111/j.1523-1755.2005.00498.x. PMID 16105036.
  10. ^ Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int. 56 (5): 1638–53. doi:10.1046/j.1523-1755.1999.00720.x. PMID 10571772.
  11. ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
  12. ^ a b Slavin R, Hutcheson P, Chauhan B, Bellone C (2004). "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc. 25 (6): 395–9. PMID 15709450.
  13. ^ a b Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Judge F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens. 61 (2): 166–71. doi:10.1046/j.0001-2815.2002.00008.x. PMID 12694585.
  14. ^ Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". International Journal of Immunogenetics. 32 (3): 173–8. doi:10.1111/j.1744-313X.2005.00504.x. PMID 15932622.
  15. ^ Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet. 6 (2): 157–62. doi:10.1038/ng0294-157. PMID 8162070.
  16. ^ Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum. 50 (3): 882–91. doi:10.1002/art.20093. PMID 15022331.
  17. ^ Petrushkin, Harry; Thomas, Dhanes; Vaughan, Robert; Kondeatis, Elli; Stanford, Miles R.; Edelsten, Clive; Wallace, Graham R. (2015-04-01). "Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis". JAMA Ophthalmology. 133 (4): 482–483. doi:10.1001/jamaophthalmol.2014.5868. ISSN 2168-6165.
  18. ^ a b Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 59 (2): 113–7. doi:10.1034/j.1399-0039.2002.590206.x. PMID 12028537.
  19. ^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
  20. ^ García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem. 43 (Pt 3): 214–6. doi:10.1258/000456306776865205. PMID 16704757.
  21. ^ a b Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev. 9 (11): 1183–91. PMID 11097225.