디스크2

디스크2
식별자
에일리어스	DISC2, DISC1-AS1, DISC1OS, NCRNA00015, 정신분열증 2(비단백질 코드화), 정신분열증 2에서 중단
외부 ID	OMIM: 606271 GeneCard: DISC2
맞춤법
	27184
	없음
	ENSG00000274121
	없음
	n; a
	없음
	없음
	없음
	없음
	없음
	위키데이터
인간 보기/편집

분자생물학에서, DISC2로도 알려진 정신분열증 2(비단백질 부호화)는 긴 비코드 RNA 분자이다.사람의 경우, DISC2 RNA 분자를 생성하는 DISC2 유전자는 정신분열증에서 ^[2]발견된 염색체 전위(translocation)와 관련된 중단점인 1번 염색체에 위치한다.이것은 DISC1 유전자에 대한 안티센스이며 DISC1의 ^[2]^[3]발현을 조절할 수 있다.DISC2는 또한 다른 정신 ^[3]^[4]질환의 원인이 될 수 있다.

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긴 비코드 RNA

레퍼런스

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics. 9 (9): 1415–1423. doi:10.1093/hmg/9.9.1415. PMID 10814723.
^ ^a ^b Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID 15478311. S2CID 36081296.
^ Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK (Nov 2004). "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics. 75 (5): 862–872. doi:10.1086/425586. PMC 1182115. PMID 15386212.

추가 정보

Kato T (Jun 2001). "Molecular genetics of bipolar disorder". Neuroscience Research. 40 (2): 105–113. doi:10.1016/s0168-0102(01)00221-8. PMID 11377748. S2CID 44440932.
Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ (Aug 2001). "Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family". American Journal of Human Genetics. 69 (2): 428–433. doi:10.1086/321969. PMC 1235314. PMID 11443544.
Devon RS, Anderson S, Teague PW, Burgess P, Kipari TM, Semple CA, Millar JK, Muir WJ, Murray V, Pelosi AJ, Blackwood DH, Porteous DJ (Jun 2001). "Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder". Psychiatric Genetics. 11 (2): 71–78. doi:10.1097/00041444-200106000-00003. PMID 11525420. S2CID 10805910.
Taylor MS, Devon RS, Millar JK, Porteous DJ (Jan 2003). "Evolutionary constraints on the Disrupted in Schizophrenia locus". Genomics. 81 (1): 67–77. doi:10.1016/S0888-7543(02)00026-5. PMID 12573262.
Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID 15478311. S2CID 36081296.
Farmer A, Elkin A, McGuffin P (Jan 2007). "The genetics of bipolar affective disorder". Current Opinion in Psychiatry. 20 (1): 8–12. doi:10.1097/YCO.0b013e3280117722. PMID 17143075. S2CID 1512643.
Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK (Jan 2008). "The DISC locus in psychiatric illness". Molecular Psychiatry. 13 (1): 36–64. doi:10.1038/sj.mp.4002106. PMID 17912248.
Williams JM, Beck TF, Pearson DM, Proud MB, Cheung SW, Scott DA (Aug 2009). "A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder". American Journal of Medical Genetics Part A. 149A (8): 1758–1762. doi:10.1002/ajmg.a.32941. PMC 2909829. PMID 19606485.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10814723-2] Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics. 9 (9): 1415–1423. doi:10.1093/hmg/9.9.1415. PMID 10814723.

[pmid15478311-3] Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID 15478311. S2CID 36081296.

[pmid15386212-4] Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK (Nov 2004). "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics. 75 (5): 862–872. doi:10.1086/425586. PMC 1182115. PMID 15386212.

[1]

[2]

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