스테롤 규제 요소 결합 단백질 2

SREBF2
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1UKL
식별자
별칭	SREBF2, SREBP-2, SREBP2, bHLHd2, 스테롤 규제 요소 결합 전사 인자 2
외부 ID	OMIM: 600481 MGI: 107585 HomoloGene: 20966 GeneCard: SREBF2
유전자 위치(인간)
쳇.	22번 염색체(인간)
끝	41,907,307 bp
유전자 위치(마우스)
쳇.	15번 염색체(쥐)
끝	82,1969 bp
RNA 표현 패턴
	표현된 상단
	소뇌반구;
	추가 참조 표현식 데이터
	n/a
유전자 온톨로지
분자함수	C-8 스테롤 이소머라아제 활성; DNA 결합; 단백질 조광 활성; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA 결합 전사 계수 활성; GO:0000980 RNA 중합효소 II cis-규제 영역 시퀀스별 DNA 결합; GO:0001078, GO:0001214, GO:0001206 DNA 결합 전사 억제제 활성, RNA 중합효소 II 특이; E-box 바인딩; 단백질 C-단자 결합; GO:0001948 단백질 결합; GO:0001200, GO:0001133, GO:0001201 DNA 결합 전사 계수 활성, RNA 중합효소 II 고유;
셀룰러 컴포넌트	세포질; 막의 적분 성분; 시토솔; SREBP-SCAP-인시그 복합체; 골지 기구; 소포체 망막; 막으로 막다; 골지막; 소포체성 망막; ER에서 골기로 운반하는 방광막; GO:0016023 세포질 소실; 핵의; 핵종의; 미토콘드리온; 세포내 막으로 둘러싸인 오르가넬;
생물학적 과정	스테로이드 대사 과정; 전사 규정, DNA-템플링; 미토콘드리온을 대상으로 하는 단백질의 양성 조절; 지질 대사; 콜레스테롤 저장에 대한 양성 규제; 층류 유체 전단 응력에 대한 세포 반응; 기아에 대한 세포 반응; 콜레스테롤 대사 과정; RNA 중합효소 II에 의한 전사의 음성 조절; 전사, DNA-템플릿; 미토콘드리아 자폐증 규제; 콜레스테롤 유출에 대한 부정적인 규제; RNA 중합효소 II에 의한 전사의 양성 조절; 콜레스테롤 생합성 작용의 조절; 저밀도 지단백질 입자 자극에 대한 세포 반응;
	출처:아미고 / 퀵고
직교체
	6721
	20788
	ENSG00000198911
	ENSMUSG00000022463
	Q12772
	Q3U1N2
	NM_004599
	NM_033218
	NP_004590
	NP_150087
	위키다타
인간 보기/편집	마우스 보기/편집

스테롤 규제 요소 결합 전사 인자 2(SREBP-2)로도 알려진 스테롤 규제 요소 결합 단백질 2(SREBP-2)는 인간에서 SREBF2 유전자에 의해 인코딩되는 단백질이다.^[5]

함수

이 유전자는 스테롤 조절 유전자의 전사를 자극하여 콜레스테롤의 전지를 제어하는 보편적으로 표현되는 전사 인자를 암호로 한다. 인코딩된 단백질은 기본적인 나선형-루프-헬릭스 레우신 지퍼(bHLH-Zip) 도메인을 함유하고 있다.^[6] SREBF2의 다양한 단일 뉴클레오티드 다형성(SNP)이 확인되었으며, 그 중 일부는 무릎 골관절염의 위험성이 높은 것으로 밝혀졌다. ^[7]

상호작용

SREBF2는 INSIG1^[8]^[9] 및 CREB 결합 단백질과 상호작용하는 것으로 나타났다.^[10]

참고 항목

스테롤 조절소자결합단백질

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000198911 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000022463 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Dec 1993). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proceedings of the National Academy of Sciences of the United States of America. 90 (24): 11603–7. Bibcode:1993PNAS...9011603H. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453.
^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2".
^ Qiu XM, Jin CT, Wang W (Apr 2014). "Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population". The Journal of International Medical Research. 42 (2): 320–8. doi:10.1177/0300060513507392. PMID 24496149.
^ Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (Sep 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". The Journal of Biological Chemistry. 278 (37): 35837–43. doi:10.1074/jbc.M306476200. PMID 12842885.
^ Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS (Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell. 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038. S2CID 15052132.
^ Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891.

추가 읽기

Osborne TF (Aug 2001). "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin". Genes & Development. 15 (15): 1873–8. doi:10.1101/gad.916601. PMID 11485982.
Szolkiewicz M, Chmielewski M, Nogalska A, Stelmanska E, Swierczynski J, Rutkowski B (Jan 2007). "The potential role of sterol regulatory element binding protein transcription factors in renal injury". Journal of Renal Nutrition. 17 (1): 62–5. doi:10.1053/j.jrn.2006.10.009. PMID 17198935.
Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH (Feb 1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics. 25 (3): 667–73. doi:10.1016/0888-7543(95)80009-B. PMID 7759101.
Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (Oct 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell. 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897. S2CID 2784016.
Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL (Mar 1996). "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis". The EMBO Journal. 15 (5): 1012–20. doi:10.1002/j.1460-2075.1996.tb00438.x. PMC 449996. PMID 8605870.
Hua X, Sakai J, Brown MS, Goldstein JL (Apr 1996). "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane". The Journal of Biological Chemistry. 271 (17): 10379–84. doi:10.1074/jbc.271.17.10379. PMID 8626610.
Pai JT, Brown MS, Goldstein JL (May 1996). "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5437–42. Bibcode:1996PNAS...93.5437P. doi:10.1073/pnas.93.11.5437. PMC 39264. PMID 8643593.
Sato R, Inoue J, Kawabe Y, Kodama T, Takano T, Maeda M (Oct 1996). "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2". The Journal of Biological Chemistry. 271 (43): 26461–4. doi:10.1074/jbc.271.43.26461. PMID 8900111.
Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891.
Miserez AR, Cao G, Probst LC, Hobbs HH (Feb 1997). "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)". Genomics. 40 (1): 31–40. doi:10.1006/geno.1996.4525. PMID 9070916.
Duncan EA, Brown MS, Goldstein JL, Sakai J (May 1997). "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2". The Journal of Biological Chemistry. 272 (19): 12778–85. doi:10.1074/jbc.272.19.12778. PMID 9139737.
Harris IR, Farrell AM, Holleran WM, Jackson S, Grunfeld C, Elias PM, Feingold KR (Feb 1998). "Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis". Journal of Lipid Research. 39 (2): 412–22. doi:10.1016/S0022-2275(20)33902-X. PMID 9508001.
Kan HY, Pissios P, Chambaz J, Zannis VI (Feb 1999). "DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter". Nucleic Acids Research. 27 (4): 1104–17. doi:10.1093/nar/27.4.1104. PMC 148292. PMID 9927745.
Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M (Feb 1999). "Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1321–6. Bibcode:1999PNAS...96.1321S. doi:10.1073/pnas.96.4.1321. PMC 15461. PMID 9990022.
Nagoshi E, Imamoto N, Sato R, Yoneda Y (Jul 1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip". Molecular Biology of the Cell. 10 (7): 2221–33. doi:10.1091/mbc.10.7.2221. PMC 25438. PMID 10397761.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ (Dec 1999). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi". Cell. 99 (7): 703–12. doi:10.1016/S0092-8674(00)81668-2. PMID 10619424.
Kotzka J, Müller-Wieland D, Roth G, Kremer L, Munck M, Schürmann S, Knebel B, Krone W (Jan 2000). "Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade". Journal of Lipid Research. 41 (1): 99–108. doi:10.1016/S0022-2275(20)32079-4. PMID 10627507.
Yang T, Goldstein JL, Brown MS (Sep 2000). "Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum". The Journal of Biological Chemistry. 275 (38): 29881–6. doi:10.1074/jbc.M005439200. PMID 10896675.

외부 링크

SREBF2+단백질,+인간(US National Library of Medicine Medical Pubject Headings, MesSH)
팩터북 SREBP2

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000198911 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000022463 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7903453-5] Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Dec 1993). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proceedings of the National Academy of Sciences of the United States of America. 90 (24): 11603–7. Bibcode:1993PNAS...9011603H. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453.

[entrez-6] "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2".

[pmid_=_24496149-7] Qiu XM, Jin CT, Wang W (Apr 2014). "Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population". The Journal of International Medical Research. 42 (2): 320–8. doi:10.1177/0300060513507392. PMID 24496149.

[pmid12842885-8] Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (Sep 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". The Journal of Biological Chemistry. 278 (37): 35837–43. doi:10.1074/jbc.M306476200. PMID 12842885.

[pmid12202038-9] Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS (Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell. 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038. S2CID 15052132.

[pmid8918891-10] Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891.

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스테롤 규제 요소 결합 단백질 2

네임스페이스

더

목차

함수

상호작용

참고 항목

참조

추가 읽기

외부 링크