PPP2R1A
PPP2R1A
세린/스레오닌-단백질인산효소 2A 65kDa 규제 하위단위 알파 이소포형은 인간에서 PPP2R1A 유전자에 의해 인코딩되는 효소다.[5]아라비도피스탈리아나 식물에서는 유사한 효소가 RCN1유전자(At1g25490)에 의해 부호화된다.[6]
함수
이 유전자는 단백질인산효소 2의 일정한 규제 하위 단위를 암호화한다.단백질인산화효소 2는 4대 Ser/Thrphosphatase 중 하나로 세포 성장과 분열을 부정적으로 제어하는 데 관여한다.그것은 촉매 서브유닛과 상수 규제 서브유닛으로 구성되어 다양한 규제 서브유닛과 연관되어 있는 공통 이질성 코어 효소로 구성된다.일정한 규제 서브 유닛 A는 촉매 서브 유닛과 가변 규제 B 서브 유닛의 조립을 조정하는 비계 분자의 역할을 한다.이 유전자는 상수 규제 소단위 A의 알파 이소형을 인코딩한다.[7]
상호작용
PPP2R1A는 다음과 상호작용하는 것으로 나타났다.
아라비도피스 RCN1
RCN1 At1g25490은 아라비도피스 인광프로테아제 2A 규제 서브유닛 A(PP2Aa) 인코딩의 3개 유전자 중 하나이다.PP2Aa-PP2ac 조광기와 다른 b 하위 유니트의 연관성은 기질 특수성을 결정하는 것으로 간주된다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000105568 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000007564 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Everett AD, Xue C, Stoops T (August 1999). "Developmental expression of protein phosphatase 2A in the kidney". J. Am. Soc. Nephrol. 10 (8): 1737–45. doi:10.1681/ASN.V1081737. PMID 10446941.
- ^ Haynes JG, Hartung AJ, Hendershot JD, Passingham RS, Rundle SJ (February 1999). "Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A". Eur. J. Biochem. 260 (1): 127–136. doi:10.1046/j.1432-1327.1999.00154.x. PMID 10091592.
- ^ "Entrez Gene: PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform".
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- ^ a b c d e Zhou J, Pham HT, Ruediger R, Walter G (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
- ^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (October 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". J. Biol. Chem. 283 (43): 29273–29284. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
- ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
추가 읽기
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- Walter G, Ruediger R, Slaughter C, Mumby M (1990). "Association of protein phosphatase 2A with polyoma virus medium tumor antigen". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2521–2525. doi:10.1073/pnas.87.7.2521. PMC 53721. PMID 2157202.
- Hemmings BA, Adams-Pearson C, Maurer F, et al. (1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–3173. doi:10.1021/bi00465a002. PMID 2159327.
- Walter G, Ferre F, Espiritu O, Carbone-Wiley A (1989). "Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8669–8672. doi:10.1073/pnas.86.22.8669. PMC 298349. PMID 2554323.
- McCright B, Virshup DM (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem. 270 (44): 26123–26128. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- Ruediger R, Hentz M, Fait J, et al. (1994). "Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens". J. Virol. 68 (1): 123–9. doi:10.1128/JVI.68.1.123-129.1994. PMC 236271. PMID 8254721.
- Zolnierowicz S, Van Hoof C, Andjelković N, et al. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". Biochem. J. 317 (1): 187–94. doi:10.1042/bj3170187. PMC 1217462. PMID 8694763.
- Tung HY, De Rocquigny H, Zhao LJ, et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886. S2CID 23293768.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–443. doi:10.1006/viro.1997.8873. PMID 9400615.
- Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". J. Virol. 73 (1): 839–42. doi:10.1128/JVI.73.1.839-842.1999. PMC 103900. PMID 9847399.
- Groves MR, Hanlon N, Turowski P, et al. (1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell. 96 (1): 99–110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501. S2CID 14465060.
- Hong Y, Sarge KD (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2". J. Biol. Chem. 274 (19): 12967–12970. doi:10.1074/jbc.274.19.12967. PMID 10224043.
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- Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–669. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.
- Ruteshouser EC, Ashworth LK, Huff V (2001). "Absence of PPP2R1A mutations in Wilms tumor". Oncogene. 20 (16): 2050–2054. doi:10.1038/sj.onc.1204301. PMID 11360189.
- Lubert EJ, Hong Y, Sarge KD (2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5". J. Biol. Chem. 276 (42): 38582–38587. doi:10.1074/jbc.M106906200. PMID 11504734.
- Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413.
- Li X, Virshup DM (2002). "Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A". Eur. J. Biochem. 269 (2): 546–552. doi:10.1046/j.0014-2956.2001.02680.x. PMID 11856313.
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