보존올리고머복합체 서브유닛5 는 COG5유전자 에 [5] [6] [7] 단백질 이다.
다단백질복합체는 골지체 구조의 주요 결정인자이며, 골지체 구조의 세포내 수송 및 당단백질 수식을 위한 용량이다. 골지 운반 복합체(GTC), 글리코실화 반응에 관여하는 LDLC 복합체, 소포 운반에 관여하는 SEC34 복합체를 포함한 여러 복합체가 확인되었다. 이 세 가지 복합체는 동일하며 COG5를 포함하는 보존 올리고머 골지(COG) 복합체라고 불린다(Ungar et al., 2002). [OMIM [7]
상호 작용 COG5는 COG7 [8] COG4 와 [8] 것 으로 나타났다.
레퍼런스 ^ a b c ENSG00000284369 GRCh38: 앙상블 릴리즈 89: ENSG00000164597, ENSG00000284369 - Ensembl , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035933 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Walter DM, Paul KS, Waters MG (Dec 1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport" . J Biol Chem . 273 (45): 29565–76. doi :10.1074/jbc.273.45.29565 PMID 9792665 . ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function" . J Cell Biol . 157 (3): 405–15. doi :10.1083/jcb.200202016 . PMC 2173297 PMID 11980916 . ^ a b "Entrez Gene: COG5 component of oligomeric golgi complex 5" .^ a b Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex" . J. Biol. Chem . United States. 279 (23): 24640–8. doi :10.1074/jbc.M400662200 ISSN 0021-9258 . PMID 15047703 .
추가 정보 Chen X, Bykhovskaya Y, Tidow N, et al. (2000). "The familial mediterranean fever protein interacts and colocalizes with a putative Golgi transporter". Proc. Soc. Exp. Biol. Med . 224 (1): 32–40. doi :10.1046/j.1525-1373.2000.22362.x . PMID 10782044 . Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp" . J. Biol. Chem . 277 (24): 21955–61. doi :10.1074/jbc.M202326200 PMID 11929878 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex" . J. Biol. Chem . 279 (23): 24640–8. doi :10.1074/jbc.M400662200 PMID 15047703 . Oka T, Vasile E, Penman M, et al. (2005). "Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells" . J. Biol. Chem . 280 (38): 32736–45. doi :10.1074/jbc.M505558200 PMID 16051600 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . 외부 링크
